Supplementing with Melatonin, Vitamin C, and Nitric Oxide for COVID-19 – A Simple Guide

"Melatonin, nitric oxide and ascorbic acid can reduce COVID-19 virulence by inhibiting NLRP3 inflammasomes to stop the perpetuation of cytokine storms. Their critical roles in biochemical reactions and biological pathways that involve ACE2 must be fully explored as part of our fight against COVID-19."

Read the full article from which this information was taken at: COVID-19, PNEUMONIA & INFLAMMASOMES – THE MELATONIN CONNECTION**

I (Jim Meehan, MD) have merely edited, organized, and added links and references to the Healthline article on nitric oxide. The credit for this work goes to Doris Loh and Healthline.

Please understand the following is NOT MEDICAL ADVICE. Please consult your trusted physician regarding COVID-19 treatment, especially if you have comorbidities like CVD, hypertension, diabetes, respiratory diseases and cancer.

What follows are two CoVID 19 scenarios, 1. Prevention and 2. Acute/Active Infection:


A. Melatonin

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Exogenous intake during COVID-19 is recommended only because normal endogenous production for adults may not be adequate for protection against COVID-19. Children under nine are protected from COVID-19 because they have up to TEN TIMES the ‘normal’ amount of adults. Our high tech environment, light pollution at night have already vastly diminished the normally low level of melatonin in adults. Supplementing with a minimum physiological dose during COVID-19 pandemic can provide additional protection against infections.

If you are an adult without major health challenges, you should take no more than the physiological dosage recommended below.

The following dosage is a range. The higher end of the range applies to people who are older or have slightly weaker health. So if you are a young healthy adult, you may require no more than the lowest physiological dose of 0.2 mg.

Physiological dose: 0.2 milligram to 0.5 milligram per day

Please take melatonin at night, about 1 to 2 hours before sleep and 2 to 3 hours AFTER your last meal. You should ideally finish eating before it is dark.

It is also extremely helpful if you can lower your ambient lighting at night, as the lowest amount of light will disrupt melatonin production. Melatonin is produced in all cells, including mitochondria, not just in pineal glands [100].

B. Vitamin C (Ascorbic Acid)

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Again, your age matters because of the level of endogenous melatonin. If you are older or more susceptible to COVID-19 for various reasons, your maintenance dose should be one gram per hour, to total 10-18 grams per day, depending on your tolerance level. You will experience loose stools, or what is known as hitting Bowel Tolerance if you have saturated your system with ascorbic acid.

C. Nitric Oxide

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Read and follow this article: "5 Ways to Increase Nitric Oxide Naturally"

Specific references on CoVID 19 and Nitric Oxide:


If you suspect infection, notify authorities in charge and your physician immediately. If you are self-quarantined at home, the following dosage applies:

A. Melatonin

Melatonin COVID-19 Infection Dosage: 5 milligrams to 50 milligrams

The lower range are for people with mild or no symptoms. The higher range is for older people or those with more severe symptoms.

IF you are taking ACE inhibitors, have cardiac conditions, hypertension, you need to consult your physician before taking high doses of melatonin.

The Infection dose should ideally be divided into DAYTIME and NIGHTTIME doses.

DAYTIME – 40% of total daily dose, divided into small equal portions to be taken every TWO HOURS.
NIGHTTIME – 60% of total daily dose, divided into two portions taken 2-3 hours after dinner. The final dose at night should be completed by 10 pm (latest).

IF you are diabetic, or have insulin resistance, DO NOT TAKE MELATONIN before 3 pm. Melatonin is able to suppress insulin.
Please remember that oral dosage higher than physiological concentration is applicable during infections only. Supplementation of high dose melatonin MUST BE SUPPORTED by ascorbic acid. You may not experience full benefits of melatonin in the absence of ascorbic acid.

B. Vitamin C (Ascorbic Acid)

Ascorbic Acid COVID-19 Infection Dosage: 1 gram every 15 to 30 minutes, depending on severity of symptoms. Increase to 2 grams every 15 to 30 minutes if symptoms are not reversed within 12-24 hours.

IF you are infected, you will essentially have an ‘unlimited’ tolerance for ascorbic acid. Your tolerance may increase above 100 grams or more. That is normal.

During infection, rest, drink plenty of purified water. You may lose your appetite. Do not force yourself to eat if you are not hungry. Calorie restriction initiates mitophagy and autophagy, which will facilitate healing [101].

[91] High Nitric Oxide Production in Human Paranasal Sinuses – PubMed…/…
[92] Infant nasal nitric oxide over time: natural evolution and impact of respiratory tract infection | European Respiratory Society
[93] Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
[94]COVID-19, Furins & Hypoxia – The Vitamin C Connection –…/
[95] 5G, Mitochondria & Coronavirus – A Tale of Depolarization –…/
[96]] Mitochondria & The Coronavirus – The Vitamin C Connection (Part 3) –…/
[97] COVID-19 Mutations, Vaccines & Nitric Oxide – The Vitamin C Connection –…/
[98] Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS…/305624280VitaminC_inhibits…
[99] Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension | Cardiovascular Research | Oxford Academic…/…/doi/10.1093/cvr/cvz312/5644338…
[100] ALAN Various Taxa Review!! Light Pollution, Circadian Photoreception, and Melatonin in Vertebrates | HTML
[101] Mitophagy plays a central role in mitochondrial ageing

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